Reply to the following discussion by supporting the post. You will want to focus on their point of view, asking pertinent questions, adding to the responses by including information from other sources. Be objective, clear, and concise.
It is important to support what you say with relevant citations in the APA format from both the course materials and outside resources.
LH Discussion:
It is necessary to critically appraise research to ensure that only relevant information is discovered and considered evidence based. The following research article was selected to investigate the potential for serious harms associated with SSRI/SNRI antidepressants. It was a systematic review, meta-analysis, and quantitative designed study related to the following PICOT question: In adolescent and young adults ages 13-25 diagnosed with depression (P), does treatment with antidepressant medications (I) compared to an alternative therapy (C) result in an increase in violent and/or suicidal behaviors (O) over a period of twelve months (T)?
Why was the study done?
The purpose of this study was to evaluate the risk of suicide and aggression in children being treated with antidepressants. It was difficult for this research team to find published trial reports that included harms associated with antidepressants; therefore, they chose to analyze the clinical study reports conducted by drug companies for market approval. It was recommended, based on this study’s outcomes, that treatment with antidepressants in children and adolescents be avoided if possible because the risk of developing violent/aggressive behavior and/or suicide doubled (Sharma, Guski, Freund, & Gotzsche, 2016).
What is the sample size?
This study was a systematic meta-analysis review of approximately seventy double blind placebo-controlled trials. The researchers reviewed about 18,526 patient records that within the documentation reported harms experienced with taking SSRI or SNRI antidepressants. The harms included in the study had to be documented from patient narratives or provider listed harms per patient evaluation. The primary adverse effects under review were mortality, suicidality, violent behavior, and akathisia. Akathisia has been defined as a heightened state of restlessness and can increase the patient’s risk for suicide and violence (Sharma et al., 2016, Introduction). The cases examined were pulled from European and UK drug regulatory reports of five common SSRI antidepressants including: Cymbalta, Paxil, Zoloft, Prozac, and Effexor. In addition to this, some study reports were also obtained from Eli Lily’s website for Prozac and Cymbalta.
Are instruments of the variables in the study clearly defined and reliable?
Sample Solution