De-prescribing

What is the importance of de-prescribing? How might you assist a patient to taper from a medication safely or transition to a new medication?

In this Assignment, you will use the following patient examples to write a 5- to 6-page paper on considerations you have for how you might de-prescribe. Support your answers with five (5) evidence-based, peer-reviewed scholarly literature resources outside of Required Learning Resources in this course.

Note: APA style format guidelines will apply.

Patient Examples:

Patient 1: A 36-year-old male presents to your office being prescribed by his primary care physician (PCP) for the past 3 years an opioid analgesic medication for a work accident. He has chronic pain and is attending a pain clinic. It is determined the best course of treatment for pain is to remain on opioid medication. The patient is also being prescribed clonazepam 1mg BID for relaxation and panic attacks.

Patient 2: A 42-year-old female on alprazolam 1mg BID for panic attacks. Panic attacks have been in remission and the patient wants to taper off the medication. But, every time she has attempted to do so in the past, she experienced withdrawal effects. She is wondering how to safely taper off the benzodiazepine medication without having withdrawal effects.

Patient 3: A 24-year-old female prescribed lorazepam 1mg TID for generalized anxiety disorder. She recently found out she is pregnant (9 weeks gestation). She was referred to you by her OB-GYN to discuss this medication for her current situation. The patient is wondering if she can stay on the lorazepam through her pregnancy and postpartum, as it is an effective medication for anxiety symptoms. She plans to exclusively breastfeed for the first 6 months postpartum. She has not had any other trials of medication to treat anxiety as lorazepam has been effective.

Patient 4: A 71-year-old-male who comes to see you at the insistence of his daughter. His daughter expresses concern of memory loss and is wondering if he has the beginning stages of dementia. He is forgetful and seems to be tripping on things or walking into walls, although he has lived in the same home for the past 35 years. The patient does not agree with his daughter but does admit he has had a few stumbles and falls lately. Medication reconciliation shows the following medications: metoprolol ER 50mg q day, omeprazole 20mg q day, clonazepam 1mg TID, levothyroxine 75mcg q am. His daughter is wondering if he should be started on a dementia medication.

Full Answer Section

       
    • Reducing the Reproduction Number (R0): Lockdowns were intended to bring the R0 (the average number of people one infected person will infect) below 1.0. When R0 is below 1, the epidemic will eventually decline as each infected person infects fewer than one other person on average.  
    • Buying Time: Lockdowns provided crucial time for healthcare systems to prepare, for scientists to better understand the virus, and for the development and deployment of testing, treatments, and eventually vaccines.
  1. Protecting Vulnerable Populations:

    • High-Risk Groups: Certain populations, such as the elderly, individuals with underlying health conditions (e.g., heart disease, diabetes, respiratory illnesses), and the immunocompromised, were at significantly higher risk of severe illness, hospitalization, and death from COVID-19.  
    • Shielding Effect: Lockdowns indirectly protected these vulnerable groups by reducing the overall level of virus circulation in the community. This decreased the likelihood of them being exposed to the virus.
    • Preventing Overwhelming Vulnerable Care Facilities: Lockdowns helped prevent outbreaks in long-term care facilities and other settings housing vulnerable individuals, where the consequences of infection could be devastating.
  2. Preserving Healthcare Systems:

    • Preventing Overcapacity: A rapid and uncontrolled surge of COVID-19 cases could quickly overwhelm hospital capacity, leading to shortages of beds, ventilators, healthcare staff, and other essential resources.  
    • Maintaining Quality of Care: When healthcare systems are overwhelmed, the quality of care for all patients, not just those with COVID-19, can suffer. Lockdowns aimed to "flatten the curve" of the epidemic, spreading out cases over time and ensuring that hospitals could manage the influx of patients without being completely overwhelmed.
    • Protecting Healthcare Workers: Lockdowns helped reduce the risk of infection among healthcare workers, who were essential for responding to the pandemic and maintaining other critical healthcare services.

Addressing Counterarguments Regarding Infringements on Civil Liberties:

Lockdowns undeniably involved significant restrictions on fundamental rights and freedoms, including:

  • Freedom of movement: Restrictions on leaving one's home, travel bans.
  • Freedom of assembly: Bans on gatherings, closure of public spaces.  
  • Freedom to work and conduct business: Closure of non-essential businesses, job losses.  
  • Right to education: Closure of schools and universities, disruption of learning.
  • Right to social and cultural participation: Closure of cultural institutions, cancellation of events.

The justification for these infringements in a public health crisis rests on several key ethical principles:

  • The Principle of Beneficence: This principle obligates healthcare professionals and public health authorities to act in the best interests of the population and to prevent harm. In the face of a highly contagious and potentially deadly virus, lockdowns were argued to be a necessary measure to maximize benefit by saving lives and preventing severe illness.
  • The Principle of Non-Maleficence: This principle requires avoiding harm. By reducing transmission and preventing healthcare system collapse, lockdowns aimed to minimize the overall harm caused by the pandemic, even if they caused individual hardship.
  • The Principle of Justice: Public health measures should be implemented fairly and equitably. While lockdowns affected everyone, they were argued to be necessary to protect the most vulnerable members of society who would disproportionately suffer the consequences of uncontrolled spread. The aim was to ensure that everyone had a chance to access necessary healthcare.
  • The Harm Principle: This principle, articulated by John Stuart Mill, suggests that the only justification for limiting individual liberty is to prevent harm to others. During a pandemic, an individual's actions (e.g., going to a crowded place while infected) can directly harm others. Lockdowns can be seen as a way to prevent this harm on a large scale.
  • The Social Contract: In times of crisis, individuals implicitly agree to cede some personal freedoms to the state in exchange for protection and the maintenance of social order. Lockdowns can be viewed as a temporary measure within this social contract, taken to safeguard the collective well-being.

Why These Measures Are Ethically Warranted in a Public Health Crisis:

The ethical justification for lockdowns hinges on the understanding that individual liberties are not absolute and can be justifiably limited when necessary to prevent significant harm to others and to protect the overall health of the community. The severity of the COVID-19 pandemic, characterized by its high transmissibility, potential for severe illness and death, and the risk of overwhelming healthcare systems, created a situation where extraordinary measures were deemed necessary.

However, the ethical warrant for lockdowns came with important caveats:

  • Proportionality: The restrictions imposed should be proportionate to the threat posed by the virus. As understanding of the virus evolved and alternative measures became available (e.g., vaccines), the necessity and scope of lockdowns needed to be re-evaluated.
  • Necessity: Lockdowns should only be implemented when less restrictive measures are insufficient to control the spread of the virus and protect public health.
  • Transparency and Accountability: The rationale for lockdowns, their duration, and their impact should be clearly communicated to the public. Governments should be accountable for the decisions made and the consequences of these measures.
  • Equity and Support: Governments have a responsibility to mitigate the negative consequences of lockdowns, such as economic hardship and social isolation, by providing adequate support to affected individuals and businesses.  
  • Regular Review and Sunset Clauses: Lockdowns should be subject to regular review and have sunset clauses to ensure they are not maintained longer than absolutely necessary.

In conclusion, while COVID-19 lockdowns represented significant infringements on civil liberties, they can be ethically justified as necessary public health measures in the face of an unprecedented crisis. The arguments for virus containment, protecting vulnerable populations, and preserving healthcare systems, grounded in principles of beneficence, non-maleficence, justice, and the harm principle, provided a strong rationale for these interventions. However, their ethical warrant depended on their proportionality, necessity, transparency, equitable implementation, and regular review. The debate surrounding lockdowns highlights the inherent tension between individual freedoms and the collective responsibility to protect public health, a tension that requires careful consideration and ethical reasoning, especially during times of crisis.  

Sample Answer

     

Justifying COVID-19 lockdowns as necessary public health measures rather than acts of oppression requires a careful examination of the ethical principles at play and a thorough understanding of the pandemic's dynamics. While lockdowns undeniably involved significant restrictions on individual freedoms, the main arguments in their support center on the need to protect the collective health and well-being of the population during an unprecedented public health crisis.

Main Arguments in Support of Lockdowns:

  1. Virus Containment and Transmission Reduction:

    • Slowing the Spread: The primary goal of lockdowns was to drastically reduce the rate of SARS-CoV-2 transmission. By limiting social interactions, closing non-essential businesses, and restricting movement, lockdowns aimed to break chains of infection and prevent exponential growth of cases.