Diagnosis and Management of Anemia Based on CBC Findings: Identifying Type and Treatment Approach"

What is the most likely diagnosis for a patient with the following CBC findings? WBC: 8.8 × 103/µl; RBC: 3.01 × 103/µl; Hgb: 10.3 g/dL; Hct: 32.2%; MCV: 74 fL; MCHC: 28.3 g/dL; Plt: 400 × 103/µl; RDW: 18.4%; Reticulocytes: 2.1%.

Identify which anemia is the patient experiencing, which tests should be ordered and what type of treatment should be followed.

Sample Answer

       

This patient's CBC findings are suggestive of iron-deficiency anemia, which is the most likely diagnosis.

Here's why:

  • Low RBC, Hgb, and Hct: These are the key indicators of anemia, meaning the patient has a lower than normal number of red blood cells and reduced hemoglobin, leading to decreased oxygen-carrying capacity.
  • Low MCV: This indicates microcytic anemia, meaning the red blood cells are smaller than usual. Iron deficiency is the most common cause of microcytic anemia.
  • High RDW: The red cell distribution width is high, indicating a greater variation in the size of red blood cells. This is often seen in iron deficiency as the bone marrow struggles to produce enough normal-sized red blood cells.

Full Answer Section

         

While iron deficiency is the most likely diagnosis, other possibilities like thalassemia (also a microcytic anemia) should be considered.

To confirm the diagnosis and determine the underlying cause, the following tests should be ordered:

  • Serum iron levels: Measures the amount of iron in the blood.
  • Ferritin levels: Reflects the body's iron stores.
  • Total iron-binding capacity (TIBC): Measures the blood's capacity to bind iron.
  • Transferrin saturation: The percentage of transferrin that is bound to iron.
  • Blood smear examination: A microscopic examination of the blood cells to look for abnormalities in their size, shape, and color.

The treatment will depend on the underlying cause of the anemia:

  • If iron-deficiency anemia is confirmed: Iron supplementation, either orally or intravenously, is the primary treatment. The underlying cause of the iron deficiency, such as poor dietary intake, blood loss, or malabsorption, should also be addressed.
  • If the anemia is severe: Blood transfusions may be necessary to quickly increase the number of red blood cells and improve oxygen delivery to the tissues.