Hematopoietic

J.D. is a 37 years old white woman who presents to her gynecologist complaining of a 2-month history of intermenstrual bleeding, menorrhagia, increased urinary frequency, mild incontinence, extreme fatigue, and weakness. Her menstrual period occurs every 28 days and lately there have been 6 days of heavy flow and cramping. She denies abdominal distension, back-ache, and constipation. She has not had her usual energy levels since before her last pregnancy.

Past Medical History (PMH):
Upon reviewing her past medical history, the gynecologist notes that her patient is a G5P5with four pregnancies within four years, the last infant having been delivered vaginally four months ago. All five pregnancies were unremarkable and without delivery complications. All infants were born healthy. Patient history also reveals a 3-year history of osteoarthritis in the left knee, probably the result of sustaining significant trauma to her knee in an MVA when she was 9 years old. When asked what OTC medications she is currently taking for her pain and for how long she has been taking them, she reveals that she started taking ibuprofen, three tablets each day, about 2.5 years ago for her left knee. Due to a slowly progressive increase in pain and a loss of adequate relief with three tablets, she doubled the daily dose of ibuprofen. Upon the recommendation from her nurse practitioner and because long-term ibuprofen use can cause peptic ulcers, she began taking OTC omeprazole on a regular basis to prevent gastrointestinal bleeding. Patient history also reveals a 3-year history of HTN for which she is now being treated with a diuretic and a centrally acting antihypertensive drug. She has had no previous surgeries.

Case Study Questions

Name the contributing factors on J.D that might put her at risk to develop iron deficiency anemia.
Within the case study, describe the reasons why J.D. might be presenting constipation and or dehydration.
Why Vitamin B12 and folic acid are important on the erythropoiesis? What abnormalities their deficiency might cause on the red blood cells?
The gynecologist is suspecting that J.D. might be experiencing iron deficiency anemia.
In order to support the diagnosis, list and describe the clinical symptoms that J.D. might have positive for Iron deficiency anemia.
If the patient is diagnosed with iron deficiency anemia, what do you expect to find as signs of this type of anemia? List and describe.
Labs results came back for the patient. Hb 10.2 g/dL; Hct 30.8%; Ferritin 9 ng/dL; red blood cells are smaller and paler in color than normal. Research list and describe for appropriate recommendations and treatments for J.D.
Cardiovascular
Mr. W.G. is a 53-year-old white man who began to experience chest discomfort while playing tennis with a friend. At first, he attributed his discomfort to the heat and having had a large breakfast. Gradually, however, discomfort intensified to a crushing sensation in the sternal area and the pain seemed to spread upward into his neck and lower jaw. The nature of the pain did not seem to change with deep breathing. When Mr. G. complained of feeling nauseated and began rubbing his chest, his tennis partner was concerned that his friend was having a heart attack and called 911 on his cell phone. The patient was transported to the ED of the nearest hospital and arrived within 30 minutes of the onset of chest pain. In route to the hospital, the patient was placed on nasal cannula and an IV D5W was started. Mr. G. received aspirin (325 mg po) and 2 mg/IV morphine. He is allergic to meperidine (rash). His pain has eased slightly in the last 15 minutes but is still significant; was 9/10 in severity; now7/10. In the ED, chest pain was not relieved by 3 SL NTG tablets. He denies chills.

Case Study Questions

For patients at risk of developing coronary artery disease and patients diagnosed with acute myocardial infarct, describe the modifiable and non-modifiable risk factors.
What would you expect to see on Mr. W.G. EKG and which findings described on the case are compatible with the acute coronary event?
Having only the opportunity to choose one laboratory test to confirm the acute myocardial infarct, which would be the most specific laboratory test you would choose and why?
How do you explain that Mr. W.G temperature has increased after his Myocardial Infarct, when that can be observed and for how long? Base your answer on the pathophysiology of the event.
Explain to Mr. W.G. why he was experiencing pain during his Myocardial Infarct. Elaborate and support your answer.

Full Answer Section

       
  • Importance:
    • Vitamin B12 and folic acid are essential for DNA synthesis, which is crucial for red blood cell (RBC) production.
    • They play a vital role in the maturation of RBCs in the bone marrow.
  • Deficiency Abnormalities:
    • Deficiencies can lead to megaloblastic anemia, characterized by large, immature RBCs (macrocytes).
    • RBCs are fragile and have a shortened lifespan, leading to anemia.
    • B12 deficiency can also cause neurological symptoms.

4. Clinical Symptoms of Iron Deficiency Anemia (J.D.):

  • Fatigue and Weakness: These are common symptoms due to reduced oxygen-carrying capacity.
  • Menorrhagia and Intermenstrual Bleeding: These are direct causes of iron loss.
  • Increased Urinary Frequency and Mild Incontinence: These can contribute to overall weakness and fatigue.
  • Pale Skin: Reduced hemoglobin results in pallor.

5. Signs of Iron Deficiency Anemia:

  • Pallor: Pale skin, conjunctiva, and mucous membranes.
  • Tachycardia: Rapid heart rate to compensate for reduced oxygen delivery.
  • Tachypnea: Rapid breathing to increase oxygen intake.
  • Koilonychia: Spoon-shaped nails (in severe cases).
  • Atrophic Glossitis: Smooth, sore tongue.

6. Recommendations and Treatments:

  • Iron Supplementation: Oral iron supplements (ferrous sulfate) are the primary treatment.
  • Dietary Changes: Increase iron-rich foods (red meat, leafy greens).
  • Address Underlying Causes: Treat menorrhagia and intermenstrual bleeding.
  • Monitor NSAID Use: Consider alternative pain management to avoid GI bleeding.
  • Vitamin C: Recommend taking vitamin C with iron supplements to enhance absorption.
  • Follow-up Labs: Regularly monitor Hb, Hct, and ferritin levels.

Case Study 2: Mr. W.G. (Myocardial Infarction)

1. Risk Factors for Coronary Artery Disease (CAD) and Acute Myocardial Infarction (AMI):

  • Non-Modifiable:
    • Age: Increased risk with advancing age.
    • Sex: Men are at higher risk than premenopausal women.
    • Family History: Genetic predisposition.
    • Race: Certain races have higher risk.
  • Modifiable:
    • Smoking: Damages blood vessels.
    • Hypertension: Increases workload on the heart.
    • Hyperlipidemia: High cholesterol leads to plaque buildup.
    • Diabetes: Damages blood vessels.
    • Obesity: Increases risk of other risk factors.
    • Sedentary Lifestyle: Lack of physical activity.
    • Stress: Contributes to hypertension and other risk factors.

2. EKG Findings and Compatible Symptoms:

  • EKG:
    • ST-segment elevation (STEMI) or depression (NSTEMI).
    • T-wave inversion.
    • Q-wave formation (indicating previous MI).
  • Compatible Symptoms:
    • Crushing chest pain radiating to the neck and jaw.
    • Nausea.
    • Chest pain not relieved by NTG.

3. Most Specific Laboratory Test:

  • Troponin: Troponin is the most specific cardiac biomarker for myocardial damage. Elevated troponin levels indicate myocardial cell death, confirming an AMI.

4. Increased Temperature After MI:

  • Pathophysiology:
    • Myocardial cell death triggers an inflammatory response.
    • Necrotic tissue releases inflammatory mediators (cytokines).
    • These mediators cause a systemic inflammatory response, leading to a mild fever.
  • Observation:
    • Temperature elevation typically occurs within 24-72 hours post-MI.
    • It is usually low-grade and transient.

5. Pain During MI:

  • Explanation:
    • Myocardial ischemia (lack of blood flow) occurs due to coronary artery blockage.
    • Ischemia leads to myocardial cell hypoxia (lack of oxygen).
    • Hypoxia causes the release of chemical mediators (e.g., bradykinin, histamine) that stimulate pain receptors.
    • These pain signals are transmitted to the central nervous system, resulting in the characteristic chest pain of an AMI.
    • The pain is caused by the bodies response to the dying heart tissue.

Sample Answer

       

Case Study 1: J.D. (Iron Deficiency Anemia)

1. Contributing Factors for Iron Deficiency Anemia:

  • Menorrhagia: Heavy menstrual bleeding leads to significant iron loss.
  • Intermenstrual Bleeding: Any abnormal bleeding contributes to iron depletion.
  • Multiple Pregnancies: Pregnancy depletes iron stores, and multiple pregnancies within a short period exacerbate this.
  • Recent Delivery: Postpartum blood loss and the demands of lactation further deplete iron.
  • Chronic NSAID Use: Long-term ibuprofen use can cause gastrointestinal bleeding, leading to iron loss.
  • Increased Urinary Frequency/Mild Incontinence: While less direct, these can indicate underlying issues that contribute to overall weakness and fatigue, which are also symptoms of anemia.

2. Constipation and Dehydration:

  • Diuretic Use: Diuretics, prescribed for hypertension, can lead to dehydration by increasing urine output. Dehydration can cause constipation.
  • Iron Supplementation (if started): Iron supplements themselves can cause constipation as a common side effect.
  • Dehydration: Dehydration itself can cause constipation.
  • Weakness and Fatigue: Due to the anemia, the patient may not be as active as usual, which can contribute to constipation.

3. Vitamin B12 and Folic Acid in Erythropoiesis: