Hematopoietic

J.D. is a 37 years old white woman who presents to her gynecologist complaining of a 2-month history of intermenstrual bleeding, menorrhagia, increased urinary frequency, mild incontinence, extreme fatigue, and weakness. Her menstrual period occurs every 28 days and lately there have been 6 days of heavy flow and cramping. She denies abdominal distension, back-ache, and constipation. She has not had her usual energy levels since before her last pregnancy.

Past Medical History (PMH):
Upon reviewing her past medical history, the gynecologist notes that her patient is a G5P5with four pregnancies within four years, the last infant having been delivered vaginally four months ago. All five pregnancies were unremarkable and without delivery complications. All infants were born healthy. Patient history also reveals a 3-year history of osteoarthritis in the left knee, probably the result of sustaining significant trauma to her knee in an MVA when she was 9 years old. When asked what OTC medications she is currently taking for her pain and for how long she has been taking them, she reveals that she started taking ibuprofen, three tablets each day, about 2.5 years ago for her left knee. Due to a slowly progressive increase in pain and a loss of adequate relief with three tablets, she doubled the daily dose of ibuprofen. Upon the recommendation from her nurse practitioner and because long-term ibuprofen use can cause peptic ulcers, she began taking OTC omeprazole on a regular basis to prevent gastrointestinal bleeding. Patient history also reveals a 3-year history of HTN for which she is now being treated with a diuretic and a centrally acting antihypertensive drug. She has had no previous surgeries.

Case Study Questions

Name the contributing factors on J.D that might put her at risk to develop iron deficiency anemia.
Within the case study, describe the reasons why J.D. might be presenting constipation and or dehydration.
Why Vitamin B12 and folic acid are important on the erythropoiesis? What abnormalities their deficiency might cause on the red blood cells?
The gynecologist is suspecting that J.D. might be experiencing iron deficiency anemia.
In order to support the diagnosis, list and describe the clinical symptoms that J.D. might have positive for Iron deficiency anemia.
If the patient is diagnosed with iron deficiency anemia, what do you expect to find as signs of this type of anemia? List and describe.
Labs results came back for the patient. Hb 10.2 g/dL; Hct 30.8%; Ferritin 9 ng/dL; red blood cells are smaller and paler in color than normal. Research list and describe for appropriate recommendations and treatments for J.D.
Cardiovascular
Mr. W.G. is a 53-year-old white man who began to experience chest discomfort while playing tennis with a friend. At first, he attributed his discomfort to the heat and having had a large breakfast. Gradually, however, discomfort intensified to a crushing sensation in the sternal area and the pain seemed to spread upward into his neck and lower jaw. The nature of the pain did not seem to change with deep breathing. When Mr. G. complained of feeling nauseated and began rubbing his chest, his tennis partner was concerned that his friend was having a heart attack and called 911 on his cell phone. The patient was transported to the ED of the nearest hospital and arrived within 30 minutes of the onset of chest pain. In route to the hospital, the patient was placed on nasal cannula and an IV D5W was started. Mr. G. received aspirin (325 mg po) and 2 mg/IV morphine. He is allergic to meperidine (rash). His pain has eased slightly in the last 15 minutes but is still significant; was 9/10 in severity; now7/10. In the ED, chest pain was not relieved by 3 SL NTG tablets. He denies chills.

Case Study Questions

For patients at risk of developing coronary artery disease and patients diagnosed with acute myocardial infarct, describe the modifiable and non-modifiable risk factors.
What would you expect to see on Mr. W.G. EKG and which findings described on the case are compatible with the acute coronary event?
Having only the opportunity to choose one laboratory test to confirm the acute myocardial infarct, which would be the most specific laboratory test you would choose and why?
How do you explain that Mr. W.G temperature has increased after his Myocardial Infarct, when that can be observed and for how long? Base your answer on the pathophysiology of the event.
Explain to Mr. W.G. why he was experiencing pain during his Myocardial Infarct. Elaborate and support your answer.

Full Answer Section

       

Constipation and Dehydration:

  • Diuretic Use: Diuretics increase urinary output, potentially leading to dehydration, which can contribute to constipation.
  • Iron Supplements (If Started): Iron supplements themselves can cause constipation as a side effect.
  • Dehydration from Blood Loss: Heavy and prolonged bleeding can lead to relative dehydration.
  • Pain Medications: Some pain medications can slow down the digestive system, causing constipation.

3. Vitamin B12 and Folic Acid in Erythropoiesis:

  • Importance:
    • Vitamin B12: Essential for DNA synthesis and red blood cell maturation.
    • Folic Acid: Also crucial for DNA synthesis and red blood cell formation.
  • Deficiency Abnormalities:
    • Macrocytic Anemia: Deficiency leads to large, immature red blood cells (megaloblasts) that are fragile and have a shortened lifespan.
    • Neurological Symptoms (B12 deficiency): B12 deficiency can also cause neurological problems due to demyelination.

4. Clinical Symptoms of Iron Deficiency Anemia:

  • Fatigue and Weakness: Due to reduced oxygen-carrying capacity.
  • Menorrhagia and Intermenstrual Bleeding: Obvious from the case.
  • Increased Urinary Frequency and Mild Incontinence: Possibly related to pelvic pressure from uterine changes or weakness.
  • Pallor: Pale skin and mucous membranes.
  • Shortness of Breath: Due to reduced oxygen delivery.
  • Headache and Dizziness: From reduced oxygen to the brain.

5. Signs of Iron Deficiency Anemia:

  • Pallor: Pale skin, conjunctiva, and nail beds.
  • Tachycardia: Rapid heart rate.
  • Tachypnea: Rapid breathing.
  • Koilonychia: Spoon-shaped nails.
  • Glossitis: Inflammation of the tongue.
  • Pica: Craving for non-nutritive substances (e.g., ice, dirt).

6. Recommendations and Treatments:

  • Iron Supplementation: Oral iron supplements (ferrous sulfate) are the first-line treatment.
  • Dietary Modifications: Increase iron-rich foods (red meat, leafy greens, fortified cereals).
  • Treat Underlying Cause: Address menorrhagia and intermenstrual bleeding through gynecological intervention.
  • NSAID Management: Discontinue or reduce ibuprofen use, and manage pain with alternative medications.
  • Monitor GI Health: Continue omeprazole to protect against ulcers.
  • Monitor Blood Counts: Regular monitoring of hemoglobin, hematocrit, and ferritin levels.
  • Possible Blood Transfusion: In severe cases, a blood transfusion may be necessary.

Mr. W.G. - Myocardial Infarction (MI)

1. Modifiable and Non-Modifiable Risk Factors for CAD/MI:

  • Non-Modifiable:
    • Age (older age increases risk).
    • Male gender (men are generally at higher risk).
    • Family history of premature CAD.
    • Race.
  • Modifiable:
    • Hypertension.
    • Hyperlipidemia.
    • Smoking.
    • Diabetes.
    • Obesity.
    • Sedentary lifestyle.
    • Stress.
    • Diet.

2. Expected EKG Findings and Compatible Symptoms:

  • EKG Findings:
    • ST-segment elevation (STEMI).
    • T-wave inversion.
    • Q waves (later finding).
  • Compatible Symptoms:
    • Crushing sternal chest pain radiating to the neck and jaw.
    • Nausea.
    • Diaphoresis (sweating).
    • Pain unrelieved by nitroglycerin.

3. Most Specific Laboratory Test:

  • Cardiac Troponin:
    • Troponin is a protein released into the bloodstream when myocardial cells are damaged. It is highly specific for myocardial injury and is the gold standard for diagnosing MI.

4. Increased Temperature After MI:

  • Pathophysiology:
    • Myocardial cell necrosis triggers an inflammatory response.
    • This inflammatory response releases cytokines, which cause a fever.
    • The temperature elevation typically occurs within 24-72 hours after the MI and usually resolves within a few days.

5. Explanation of MI Pain:

  • Ischemia and Necrosis:
    • The blockage of coronary arteries leads to ischemia (lack of blood flow) and subsequent necrosis (cell death) of the myocardial tissue.
    • Necrotic tissue releases chemical mediators that stimulate pain receptors.
    • The pain is described as crushing or squeezing due to the intense ischemia.
  • Referred Pain:
    • The pain can radiate to the neck, jaw, and left arm due to the shared nerve pathways.
    • This referred pain is a common characteristic of MI.
  • Lack of Response to Nitroglycerin:
    • Nitroglycerin dilates coronary arteries, but in a complete blockage, it cannot restore adequate blood flow to relieve the ischemic pain.

Sample Answer

     

J.D. - Anemia and Gynecological Issues

1. Contributing Factors to Iron Deficiency Anemia:

  • Menorrhagia (Heavy Menstrual Bleeding): Significant blood loss during menstruation depletes iron stores.
  • Intermenstrual Bleeding: Any additional bleeding outside the normal menstrual cycle further contributes to iron loss.
  • Recent Pregnancies: Multiple pregnancies in a short period deplete iron reserves, as iron is required for fetal development and blood volume expansion.
  • Chronic NSAID Use (Ibuprofen): Long-term NSAID use can cause gastrointestinal bleeding, leading to chronic blood loss and iron deficiency