Musculoskeletal System

SCENARIO 1

Buspirone has a half-life of approximately 2 hours. If a patient takes 15 mg at 8 am, what will the blood level be at 2 pm? Can buspirone be given as an adjunct to antidepressant therapy? Name 3 antidepressants you might prescribe for patients with co-existing depression and anxiety (include complete medication orders) and include patient monitoring.

SCENARIO 2

What are the errors (6 total) in the following prescriptions? Rewrite each prescription correctly.

methylphenidate (Concerta) 5 mg BID before breakfast and lunch #60 1 refill

pegloticase (Krystexxa) 8 mg IV infusion once per month #1 0 refill

Ubrelvy 200 mg po prn onset of migraine #12 1 refill

alprazolam (Valium) 0.5 mg po TID #90 0 refill

zolpidem 10 mg qhs #30 6 refills

SCENARIO 3

Patient TL is experiencing symptoms of daily leg muscle weakness and feet cramping at night. He is currently on metformin 1000 mg po BID, Invokamet 50/500 mg BID with meals, atorvastatin 40 mg po daily and atomoxetine 40 mg po daily. Blood pressure is 118/78 and labs include: BG 90 mg/dL A1c 4.5% sCr 0.9 mg/dL eGFR 101 mL/min/1.73 m² total cholesterol 181 mg/dL LDL 95 mg/dL HDL 57 mg/dL TG 146 mg/dL B12 150 pg/mL CK 505 U/L What is your working diagnosis? What would you prescribe for TL and how would you improve his treatment? What would you monitor?

SCENARIO 4

When a person uses nicotine, it causes temporary feelings of relaxation and well-being. Nicotine binds to nicotinic receptors in the brain, augmenting the release of numerous neurotransmitters. Name at least three of these neurotransmitters. Patients may self-medicate ADHD, anxiety and depression by smoking. Is there a medication that could treat ADHD, anxiety, depression and provide smoking cessation? Write a complete medication order for this medication. Does the patient need to quit smoking before starting treatment?

Full Answer Section

       
    • Error: "0 refill" is incorrect for a medication that is only administered once per month.
    • Correction: pegloticase (Krystexxa) 8 mg IV infusion once per month #1
  1. Ubrelvy 200 mg po prn onset of migraine #12 1 refill

    • Error: No specific instructions for frequency of use.
    • Correction: Ubrelvy 200 mg PO prn onset of migraine, maximum 1 tablet every 24 hours, #12 1 refill
  2. alprazolam (Valium) 0.5 mg po TID #90 0 refill

    • Error: Alprazolam is a short-acting benzodiazepine and should not be prescribed for long-term use.
    • Correction: alprazolam (Valium) 0.5 mg PO TID as needed for anxiety, not to exceed 4 mg daily, #90 0 refill
  3. zolpidem 10 mg qhs #30 6 refills

    • Error: Excessive refills for a potentially addictive medication.
    • Correction: zolpidem 10 mg PO at bedtime as needed for insomnia, #30 1 refill

Scenario 3

  • Working Diagnosis: Possible statin-induced myopathy.

  • Prescribe:

    • Stop atorvastatin.
    • Consider alternative lipid-lowering therapy:
      • Ezetimibe 10 mg PO daily
      • Bempedoic acid 180 mg PO daily
    • Monitor: CK levels weekly until normalized, then monthly.
    • Consult: Consider consultation with a neurologist or rheumatologist.
  • Improve Treatment:

    • Optimize glycemic control:
      • Metformin 1000 mg PO BID and Invokamet 50/500 mg BID appear appropriate.
      • Consider adding GLP-1 agonist if A1c remains above target despite current therapy.
    • Address other risk factors:
      • Encourage regular exercise:
      • Promote a healthy diet:
      • Assess for other potential causes of muscle weakness:
        • Thyroid function tests
        • Electrolytes

Scenario 4

  • Neurotransmitters: Nicotine increases the release of dopamine, norepinephrine, and acetylcholine.

  • Medication:

    • Bupropion: Bupropion is an antidepressant with dopamine and norepinephrine reuptake inhibition properties. It can be used to treat depression, seasonal affective disorder (SAD), and nicotine dependence.
    • Bupropion SR 150 mg PO daily, increase by 150 mg weekly to a maximum of 450 mg daily.
    • Monitor:
      • For side effects:
        • Agitation, insomnia, dry mouth, constipation, seizures.
      • For efficacy:
        • Monitor for nicotine withdrawal symptoms and smoking cessation.
  • Smoking Cessation:

    • While it is not always necessary to completely quit smoking before starting bupropion, it is generally recommended to reduce smoking or make a serious quit attempt.
    • Bupropion can help reduce nicotine withdrawal symptoms and cravings, making it easier to quit smoking.
 

Sample Answer

       

Scenario 1

  • Buspirone Half-Life: Buspirone has a half-life of approximately 2 hours. This means that after 2 hours, the concentration of buspirone in the blood will be reduced by half.

  • Blood Level at 2 pm: To determine the blood level at 2 pm, we need to consider that 4 hours have passed since the 8 am dose.

    • After 2 hours (10 am): 15 mg / 2 = 7.5 mg
    • After 4 hours (2 pm): 7.5 mg / 2 = 3.75 mg
    • The estimated blood level at 2 pm would be approximately 3.75 mg.
  • Buspirone as Adjunct to Antidepressants: Yes, buspirone can be used as an adjunct to antidepressant therapy in the treatment of anxiety disorders.

  • Three Antidepressants for Depression and Anxiety:

    • Sertraline 50 mg PO daily - Monitor for nausea, diarrhea, sexual dysfunction.
    • Escitalopram 10 mg PO daily - Monitor for QT prolongation, hyponatremia, sexual dysfunction.
    • Venlafaxine 75 mg PO daily - Monitor for increased blood pressure, nausea, dizziness.

Scenario 2

  1. methylphenidate (Concerta) 5 mg BID before breakfast and lunch #60 1 refill

    • Error: "BID before breakfast and lunch" is ambiguous.
    • Correction: methylphenidate (Concerta) 5 mg PO BID (morning and afternoon) #60 1 refill
  2. pegloticase (Krystexxa) 8 mg IV infusion once per month #1 0 refill