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Normal male and female karyotype
Identify a normal male and female karyotype and enumerate the number of chromosomes, autosomes, DNA content and ploidy. Interpret the short-hand notation of karyotype
Sample Answer
Normal Male Karyotype:
Number of chromosomes: 46 (23 pairs)
Number of autosomes: 44 (22 pairs)
DNA content: 6.4 billion base pairs
Ploidy: Diploid
Normal Female Karyotype:
Number of chromosomes: 46 (23 pairs)
Number of autosomes: 44 (22 pairs)
DNA content: 6.4 billion base pairs
Ploidy: Diploid
Interpretation of Karyotype Short-hand Notation:
The short-hand notation used to describe a karyotype consists of a series of numbers and letters. Let’s take an example: 46, XX.
The first number (46) represents the total number of chromosomes in the cell.
The second part (XX or XY) indicates the sex chromosomes. In this case, XX represents a female, while XY would represent a male.
If any chromosomal abnormalities or structural changes are present, they would be noted after the sex chromosome notation. For example, if there is an extra copy of chromosome 21, it would be written as 47, XX, +21 in a female or 47, XY, +21 in a male (indicating Down syndrome).